Which crosses would *not* work in your opinion? Controversial

I thought that pic was a photoshop job!

Having looked at the website - apparently not but definitely in the photo on here it does look like someone cut and pasted that head on!

I have a Weimaraner and I have heard you shouldn't mix them with other breads is this true?

LOL. Seriously!! I like to do cross breeding but never gotten enough time for it. I really hope I can do it sometime.

A Chihuahua and a great Dane? Just can't see how the practical side would work.....would need a et of stairs or something...!